Tsiolkovsky's Tyranny
The Rocket Equation is the cruelest law in physics: $$ Delta v = ve ln rac{m0}{m_f} $$ Translation: To go faster, you need more fuel. But fuel has mass. So you need more fuel to lift that fuel. It's an exponential curse.
The "90% Fuel" Rule
Look at the Saturn V rocket. 90% of it was just fuel tank. The astronauts, the ship, and the lander were a tiny speck on top. To get to Mars, we need better engines (higher Specific Impulse, or $I_{sp}$), not just bigger tanks.
Getting to Orbit is Halfway to Anywhere
Robert Heinlein famously said: *"Once you get to earth orbit, you're halfway to anywhere in the solar system."* It takes ~9.4 km/s of Delta-V to reach orbit. It only takes another ~3.6 km/s to escape Earth's gravity entirely and head to Mars.